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KMID : 0624620090420110758
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BMB Reports
2009 Volume.42 No. 11 p.758 ~ p.763
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The cancer/testis antigen CAGE induces MMP-2 through the activation of NF-κB and AP-1
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Kim Young-Mi
Jeoung Doo-Il
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Abstract
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Cancer-associated antigen (CAGE) induces the expression of matrix metalloproteinase-2 (MMP-2) by activating Akt, which in turn interacts with inhibitory kappa kinase β (IκKβ) to activate nuclear factor κB (NF-κB). Akt and p38 mitogen activated protein kinase (p38 MAPK) are necessary for CAGE-mediated induction of the AP-1 subunit JunB, whereas extracellular regulated kinase (ERK) is necessary for the induction of fos-related antigen-1 (Fra-1). Induction of MMP-2 by CAGE requires activator of protein-1 (AP-1) to be bound. Specific binding of JunB to MMP-2 promoter sequences was shown by chromatin immunoprecipitation (ChIP) analysis.
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KEYWORD
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AP-1, Cancer associated gene, Cell motility, MMP-2, NF-κB
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